Niu JP., Wu HL., Niu CH., et al. Palladium and Amino Acid Co-Catalyzed Highly Regio- and Enantioselective Hydroarylation of Unbiased Alkenes. ACS Catal. 2022, 12, XXX, 8667-8675

Abstract:

A practical palladium and amino acid co-catalyzed hydroarylation of unbiased alkenes has been developed. Using the transient-directing strategy, this chemistry could construct isolated chiral Csp2-Csp3 bonds with good regio- and enantioselectivity. The potential synthetic utility of a representative product was well-illustrated by further transformations. Furthermore, the mechanism of this reaction was intensively studied through control experiments and DFT calculations.